Signal transduction by a fungal NOD-like receptor based on propagation of a prion amyloid fold.

Signal transduction by a fungal NOD-like receptor based on propagation of a prion amyloid fold.

In the fungus Podospora anserina, the [Het-s] prion induces programmed cell death by activating the HET-S pore-forming protein. The HET-s β-solenoid prion fold serves as a template for converting the HET-S prion-forming domain into the same fold. This conversion, in turn, activates the HET-S pore-fo...

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Bibliographic Details
Main Authors: Asen Daskalov, Birgit Habenstein, Denis Martinez, Alfons J M Debets, Raimon Sabaté, Antoine Loquet, Sven J Saupe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-02-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.1002059

Internet

https://doi.org/10.1371/journal.pbio.1002059

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