HIF-1 signaling: A key orchestrator of cancer radioresistance

Hypoxia is a big roadblock for cancer radiotherapy, in which the hypoxia-inducible factor (HIF-1) creates a microenvironment and cancer cells’ intrinsic signaling networks conferring radioresistance to cancers. HIF-1 is a heterodimeric transcription factor HIF-1α/HIF-1β, that regulates the transcrip...

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Bibliographic Details
Main Authors: Ruixue Huang, Ping-Kun Zhou
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2020-03-01
Series:Radiation Medicine and Protection
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S266655572030006X