The Microbial Metabolite Butyrate Induces Expression of Th1-Associated Factors in CD4+ T Cells

The Microbial Metabolite Butyrate Induces Expression of Th1-Associated Factors in CD4+ T Cells

Short-chain fatty acids (SCFAs), which are generated by the bacterial fermentation of dietary fibers, promote expansion of regulatory T cells (Tregs). Potential therapeutic value of SCFAs has been recently highlighted in the experimental models of T cell-mediated autoimmunity and allergic inflammati...

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Bibliographic Details
Main Authors: Meike Kespohl, Niyati Vachharajani, Maik Luu, Hani Harb, Sabine Pautz, Svenja Wolff, Nina Sillner, Alesia Walker, Philippe Schmitt-Kopplin, Thomas Boettger, Harald Renz, Stefan Offermanns, Ulrich Steinhoff, Alexander Visekruna
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Immunology
Subjects:
short-chain fatty acids
butyrate
regulatory T cells
interferon-gamma
inhibition of histone deacetylase activity
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01036/full

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http://journal.frontiersin.org/article/10.3389/fimmu.2017.01036/full

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