Hypoxia-Induced LIN28A mRNA Promotes the Metastasis of Colon Cancer in a Protein-Coding-Independent Manner

Hypoxia-Induced LIN28A mRNA Promotes the Metastasis of Colon Cancer in a Protein-Coding-Independent Manner

The hypoxic microenvironment is beneficial to the metastasis but not to the proliferation of cancer cells. However, the mechanisms regarding to hypoxia differentially regulating cancer metastasis and proliferation are largely unknown. In this study, we revealed that hypoxia induced the expression of...

Full description

Bibliographic Details
Main Authors: Mingjiao Weng, Yukuan Feng, Yan He, Weiwei Yang, Jing Li, Yuanyuan Zhu, Tianzhen Wang, Chuhan Wang, Xiao Zhang, Yu Qiao, Qi Li, Lingyu Zhao, Shuangshu Gao, Lei Zhang, Yiqi Wu, Ran Zhao, Guangyu Wang, Zhiwei Li, Xiaoming Jin, Tongsen Zheng, Xiaobo Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
colon cancer
LIN28A
hypoxia
P-bodies
METAP2
metastasis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.642930/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.642930/full

Similar Items