SH2D2A modulates T cell mediated protection to a B cell derived tumor in transgenic mice.

SH2D2A modulates T cell mediated protection to a B cell derived tumor in transgenic mice.

BACKGROUND: T cell specific adapter protein (TSAd), encoded by the SH2D2A gene, modulates signaling downstream of the T cell receptor (TCR). Young, unchallenged SH2D2A-deficient C57BL/6 mice exhibit a relatively normal immune phenotype. To address whether SH2D2A regulates physiologic immune response...

Full description

Bibliographic Details
Main Authors: Tone Berge, Ingrid Helene Bø Grønningsæter, Kristina Berg Lorvik, Greger Abrahamsen, Stine Granum, Vibeke Sundvold-Gjerstad, Alexandre Corthay, Bjarne Bogen, Anne Spurkland
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3483153?pdf=render

Internet

http://europepmc.org/articles/PMC3483153?pdf=render

Similar Items