Fibronectin Modulates Cell Adhesion and Signaling to Promote Single Cell Migration of Highly Invasive Oral Squamous Cell Carcinoma.

Fibronectin Modulates Cell Adhesion and Signaling to Promote Single Cell Migration of Highly Invasive Oral Squamous Cell Carcinoma.

Cell migration is regulated by adhesion to the extracellular matrix (ECM) through integrins and activation of small RhoGTPases, such as RhoA and Rac1, resulting in changes to actomyosin organization. During invasion, epithelial-derived tumor cells switch from laminin-enriched basal membrane to colla...

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Bibliographic Details
Main Authors: Grasieli de Oliveira Ramos, Lisiane Bernardi, Isabel Lauxen, Manoel Sant'Ana Filho, Alan Rick Horwitz, Marcelo Lazzaron Lamers
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4792484?pdf=render

Internet

http://europepmc.org/articles/PMC4792484?pdf=render

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