Suppression of CD81 promotes bladder cancer cell invasion through increased matrix metalloproteinase expression via extracellular signal-regulated kinase phosphorylation

Suppression of CD81 promotes bladder cancer cell invasion through increased matrix metalloproteinase expression via extracellular signal-regulated kinase phosphorylation

Purpose: CD81 is a prognostic biomarker for high-grade bladder cancer (BC). In this study, we aimed to determine the functional mechanisms underlying the role of CD81 in BC progression. Materials and Methods: In two invasive BC cell lines (T24, J82), CD81 expression was suppressed by the transfectio...

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Bibliographic Details
Main Authors: Hyun Sik Park, Suhyuk Lee, Jisu Lee, Hyun Bin Shin, Seung-Min Yoo, Myung-Shin Lee, Jinsung Park
Format: Article
Language:English
Published: Korean Urological Association 2019-09-01
Series:Investigative and Clinical Urology
Subjects:
Disease progression
Extracellular signal-regulated MAP kinases
Matrix metalloproteinases
Tetraspanin 28
Urinary bladder neoplasms
Online Access:https://www.icurology.org/Synapse/Data/PDFData/2020ICU/icu-60-396.pdf

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https://www.icurology.org/Synapse/Data/PDFData/2020ICU/icu-60-396.pdf

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