A positive feedback loop between Flower and PI(4,5)P2 at periactive zones controls bulk endocytosis in Drosophila

A positive feedback loop between Flower and PI(4,5)P2 at periactive zones controls bulk endocytosis in Drosophila

Synaptic vesicle (SV) endocytosis is coupled to exocytosis to maintain SV pool size and thus neurotransmitter release. Intense stimulation induces activity-dependent bulk endocytosis (ADBE) to recapture large quantities of SV constituents in large endosomes from which SVs reform. How these consecuti...

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Bibliographic Details
Main Authors: Tsai-Ning Li, Yu-Jung Chen, Ting-Yi Lu, You-Tung Wang, Hsin-Chieh Lin, Chi-Kuang Yao
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-12-01
Series:eLife
Subjects:
synaptic vesicle endocytosis
Ca2+ channel
PIP2
bulk endocytosis
periactive zone
Online Access:https://elifesciences.org/articles/60125

Internet

https://elifesciences.org/articles/60125

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