IL-4Rα-dependent alternative activation of macrophages is not decisive for Mycobacterium tuberculosis pathology and bacterial burden in mice.

IL-4Rα-dependent alternative activation of macrophages is not decisive for Mycobacterium tuberculosis pathology and bacterial burden in mice.

Classical activation of macrophages (caMph or M1) is crucial for host protection against Mycobacterium tuberculosis (Mtb) infection. Evidence suggests that IL-4/IL-13 alternatively activated macrophages (aaMph or M2) are exploited by Mtb to divert microbicidal functions of caMph. To define the funct...

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Bibliographic Details
Main Authors: Reto Guler, Suraj P Parihar, Suzana Savvi, Erin Logan, Anita Schwegmann, Sugata Roy, Natalie E Nieuwenhuizen, Mumin Ozturk, Sebastian Schmeier, Harukazu Suzuki, Frank Brombacher
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4366092?pdf=render

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http://europepmc.org/articles/PMC4366092?pdf=render

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