Oxaliplatin Depolarizes the IB4– Dorsal Root Ganglion Neurons to Drive the Development of Neuropathic Pain Through TRPM8 in Mice

Oxaliplatin Depolarizes the IB4– Dorsal Root Ganglion Neurons to Drive the Development of Neuropathic Pain Through TRPM8 in Mice

Use of chemotherapy drug oxaliplatin is associated with painful peripheral neuropathy that is exacerbated by cold. Remodeling of ion channels including TRP channels in dorsal root ganglion (DRG) neurons contribute to the sensory hypersensitivity following oxaliplatin treatment in animal models. Howe...

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Bibliographic Details
Main Authors: Bin Wu, Xiaolin Su, Wentong Zhang, Yi-Hong Zhang, Xinghua Feng, Yong-Hua Ji, Zhi-Yong Tan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
oxaliplatin
neuropathic pain
dorsal root ganglion
IB4
initial drive
membrane depolarization
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2021.690858/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2021.690858/full

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