Dynamic Cross Talk between S1P and CXCL12 Regulates Hematopoietic Stem Cells Migration, Development and Bone Remodeling

Dynamic Cross Talk between S1P and CXCL12 Regulates Hematopoietic Stem Cells Migration, Development and Bone Remodeling

Hematopoietic stem cells (HSCs) are mostly retained in a quiescent non-motile mode in their bone marrow (BM) niches, shifting to a migratory cycling and differentiating state to replenish the blood with mature leukocytes on demand. The balance between the major chemo-attractants CXCL12, predominantl...

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Bibliographic Details
Main Authors: Karin Golan, Orit Kollet, Tsvee Lapidot
Format: Article
Language:English
Published: MDPI AG 2013-09-01
Series:Pharmaceuticals
Subjects:
hematopoietic stem cells
CXCL12/CXCR4
S1P
mobilization
bone remodeling
Online Access:http://www.mdpi.com/1424-8247/6/9/1145

Internet

http://www.mdpi.com/1424-8247/6/9/1145

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