Ibudilast (MN-166) in amyotrophic lateral sclerosis- an open label, safety and pharmacodynamic trial

Ibudilast (MN-166) in amyotrophic lateral sclerosis- an open label, safety and pharmacodynamic trial

Ibudilast (MN-166) is an inhibitor of macrophage migration inhibitory factor (MIF) and phosphodiesterases 3,4,10 and 11 (Gibson et al., 2006; Cho et al., 2010). Ibudilast attenuates CNS microglial activation and secretion of pro-inflammatory cytokines (Fujimoto et al., 1999; Cho et al., 2010). In vi...

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Main Authors: Suma Babu, Baileigh G. Hightower, James Chan, Nicole R. Zürcher, Pia Kivisäkk, Chieh-En J. Tseng, Danica L. Sanders, Ashley Robichaud, Haruhiko Banno, Armineuza Evora, Akshata Ashokkumar, Lindsay Pothier, Sabrina Paganoni, Sheena Chew, Joanna Dojillo, Kazuko Matsuda, Mark Gudesblatt, James D. Berry, Merit E. Cudkowicz, Jacob M Hooker, Nazem Atassi
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:NeuroImage: Clinical
Subjects:
Biomarker endpoint
Phase 1b
Clinical trial
Ibudilast
PBR28
Neurofilament
Online Access:http://www.sciencedirect.com/science/article/pii/S2213158221001169

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http://www.sciencedirect.com/science/article/pii/S2213158221001169

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