The role of hedgehog signaling in gastric cancer: molecular mechanisms, clinical potential, and perspective

Abstract Patients with advanced gastric cancer usually have a poor prognosis and limited therapeutic options. Overcoming this challenge requires novel targets and effective drugs. The Hedgehog (Hh) signaling pathway plays a crucial role in the development of the gastrointestinal tract and maintenanc...

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Bibliographic Details
Main Authors: Yan Xu, Shumei Song, Zhenning Wang, Jaffer A. Ajani
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Cell Communication and Signaling
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12964-019-0479-3