Apremilast Normalizes Gene Expression of Inflammatory Mediators in Human Keratinocytes and Reduces Antigen-Induced Atopic Dermatitis in Mice

Apremilast Normalizes Gene Expression of Inflammatory Mediators in Human Keratinocytes and Reduces Antigen-Induced Atopic Dermatitis in Mice

Abstract Background Apremilast, an oral phosphodiesterase (PDE) 4 inhibitor, has demonstrated efficacy in psoriasis, while its efficacy in atopic dermatitis (AD) was found to be modest. AD is a chronic inflammatory skin disease associated with activation of T helper (Th) 2 and Th17 immunity and a co...

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Bibliographic Details
Main Authors: Peter H. Schafer, Mary Adams, Gerald Horan, Francesca Truzzi, Alessandra Marconi, Carlo Pincelli
Format: Article
Language:English
Published: Adis, Springer Healthcare 2019-10-01
Series:Drugs in R&D
Online Access:http://link.springer.com/article/10.1007/s40268-019-00284-1

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http://link.springer.com/article/10.1007/s40268-019-00284-1

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