Presenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles

Presenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles

The development of native-like envelope trimers has been a major focus in the efforts to produce HIV vaccines. Here the authors demonstrate the production and characterization of virus-like nanoparticles displaying trimeric HIV-1 antigens with the potential to elicit broadly neutralizing antibodies.

Bibliographic Details
Main Authors: Linling He, Natalia de Val, Charles D. Morris, Nemil Vora, Therese C. Thinnes, Leopold Kong, Parisa Azadnia, Devin Sok, Bin Zhou, Dennis R. Burton, Ian A Wilson, David Nemazee, Andrew B. Ward, Jiang Zhu
Format: Article
Language:English
Published: Nature Publishing Group 2016-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12041

Internet

https://doi.org/10.1038/ncomms12041

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