Low-affinity CD4+ T cells are major responders in the primary immune response
MHC II tetramers are used to study T cell expansion but they preferentially bind high affinity T cell receptors. Here the authors show that T cells with low affinity receptors expand in number along with the T-cell repertoire and might therefore contribute more to the primary immune response than wa...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2016-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13848 |