An Essential Role for the Tetraspanin LHFPL4 in the Cell-Type-Specific Targeting and Clustering of Synaptic GABAA Receptors

An Essential Role for the Tetraspanin LHFPL4 in the Cell-Type-Specific Targeting and Clustering of Synaptic GABAA Receptors

Inhibitory synaptic transmission requires the targeting and stabilization of GABAA receptors (GABAARs) at synapses. The mechanisms responsible remain poorly understood, and roles for transmembrane accessory proteins have not been established. Using molecular, imaging, and electrophysiological approa...

Full description

Bibliographic Details
Main Authors: Elizabeth C. Davenport, Valentina Pendolino, Georgina Kontou, Thomas P. McGee, David F. Sheehan, Guillermo López-Doménech, Mark Farrant, Josef T. Kittler
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Cell Reports
Subjects:
GABAA receptor
LHFPL4 knockout
GARLH
accessory protein
LHFPL3
plasticity
interneuron
neuroligin
mIPSC
gephyrin
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717313001

Internet

http://www.sciencedirect.com/science/article/pii/S2211124717313001

Similar Items