Maternal Immunity and Vaccination Influence Disease Severity in Progeny in a Novel Mast Cell-Deficient Mouse Model of Severe Dengue

Maternal Immunity and Vaccination Influence Disease Severity in Progeny in a Novel Mast Cell-Deficient Mouse Model of Severe Dengue

Sub-neutralizing concentrations of antibodies in dengue infected patients is a major risk factor for the development of dengue hemorrhagic fever and dengue shock syndrome. Here, we describe a mouse model with a deficiency in mast cells (MCs) in addition to a deficiency in Type-I and II IFN receptors...

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Bibliographic Details
Main Authors: Chinmay Kumar Mantri, Gayathri Soundarajan, Wilfried A. A. Saron, Abhay P. S. Rathore, Sylvie Alonso, Ashley L. St. John
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Viruses
Subjects:
dengue
maternal immunity
mast cells
vaccines
Online Access:https://www.mdpi.com/1999-4915/13/5/900

Internet

https://www.mdpi.com/1999-4915/13/5/900

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