Alignment and prediction of cis-regulatory modules based on a probabilistic model of evolution.

Cross-species comparison has emerged as a powerful paradigm for predicting cis-regulatory modules (CRMs) and understanding their evolution. The comparison requires reliable sequence alignment, which remains a challenging task for less conserved noncoding sequences. Furthermore, the existing models o...

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Bibliographic Details
Main Authors: Xin He, Xu Ling, Saurabh Sinha
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-03-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC2657044?pdf=render