Optimization of hydrogenobyrinic acid biosynthesis in Escherichia coli using multi-level metabolic engineering strategies

Optimization of hydrogenobyrinic acid biosynthesis in Escherichia coli using multi-level metabolic engineering strategies

Abstract Background Hydrogenobyrinic acid is a key intermediate of the de-novo aerobic biosynthesis pathway of vitamin B12. The introduction of a heterologous de novo vitamin B12 biosynthesis pathway in Escherichia coli offers an alternative approach for its production. Although E. coli avoids major...

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Bibliographic Details
Main Authors: Pingtao Jiang, Huan Fang, Jing Zhao, Huina Dong, Zhaoxia Jin, Dawei Zhang
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Microbial Cell Factories
Subjects:
Hydrogenobyrinic acid
Uroporphyrinogen III
Escherichia coli
Metabolic engineering
Ribosomal binding site libraries
Online Access:http://link.springer.com/article/10.1186/s12934-020-01377-2

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http://link.springer.com/article/10.1186/s12934-020-01377-2

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