Structural and Aggregation Features of a Human κ-Casein Fragment with Antitumor and Cell-Penetrating Properties

Structural and Aggregation Features of a Human κ-Casein Fragment with Antitumor and Cell-Penetrating Properties

Intrinsically disordered proteins play a central role in dynamic regulatory and assembly processes in the cell. Recently, a human κ-casein proteolytic fragment called lactaptin (8.6 kDa) was found to induce apoptosis of human breast adenocarcinoma MCF-7 and MDA-MB-231 cells with no cytotoxi...

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Bibliographic Details
Main Authors: Olga A. Chinak, Andrey V. Shernyukov, Sergey S. Ovcherenko, Evgeniy A. Sviridov, Victor M. Golyshev, Alexander S. Fomin, Inna A. Pyshnaya, Elena V. Kuligina, Vladimir A. Richter, Elena G. Bagryanskaya
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Molecules
Subjects:
intrinsically disordered protein
dimerization
casein micelle
disulfide bond
β-mercaptoethanol adduct
Online Access:https://www.mdpi.com/1420-3049/24/16/2919

Internet

https://www.mdpi.com/1420-3049/24/16/2919

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