Vaccination Against Amyloidogenic Aggregates in Pancreatic Islets Prevents Development of Type 2 Diabetes Mellitus

Vaccination Against Amyloidogenic Aggregates in Pancreatic Islets Prevents Development of Type 2 Diabetes Mellitus

Type 2 diabetes mellitus (T2DM) is a chronic progressive disease characterized by insulin resistance and insufficient insulin secretion to maintain normoglycemia. The majority of T2DM patients bear amyloid deposits mainly composed of islet amyloid polypeptide (IAPP) in their pancreatic islets. These...

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Bibliographic Details
Main Authors: Elisa S. Roesti, Christina N. Boyle, Daniel T. Zeman, Marcos Sande-Melon, Federico Storni, Gustavo Cabral-Miranda, Alexander Knuth, Thomas A. Lutz, Monique Vogel, Martin F. Bachmann
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Vaccines
Subjects:
islet amyloid polypeptide
amyloid
t2dm
virus-like particle
vaccine
Online Access:https://www.mdpi.com/2076-393X/8/1/116

Internet

https://www.mdpi.com/2076-393X/8/1/116

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