Enhancement of select cognitive domains with rosiglitazone implicates dorsal hippocampus circuitry sensitive to PPARγ agonism in an Alzheimer's mouse model

Enhancement of select cognitive domains with rosiglitazone implicates dorsal hippocampus circuitry sensitive to PPARγ agonism in an Alzheimer's mouse model

Abstract Introduction Several clinical studies have tested the efficacy of insulin‐sensitizing drugs for cognitive enhancement in Alzheimer's disease (AD) patients, as type 2 diabetes (T2D) is a well‐recognized risk factor for AD. Pilot studies assessing FDA‐approved diabetes drugs in subjects...

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Bibliographic Details
Main Authors: IbDanelo Cortez, Caterina M. Hernandez, Kelly T. Dineley
Format: Article
Language:English
Published: Wiley 2021-02-01
Series:Brain and Behavior
Subjects:
context discrimination
fear conditioning
hippocampus
learning and memory
Morris water maze
PPARγ
Online Access:https://doi.org/10.1002/brb3.1973

Internet

https://doi.org/10.1002/brb3.1973

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