Pleiotropic Clostridioides difficile Cyclophilin PpiB Controls Cysteine-Tolerance, Toxin Production, the Central Metabolism and Multiple Stress Responses

Pleiotropic Clostridioides difficile Cyclophilin PpiB Controls Cysteine-Tolerance, Toxin Production, the Central Metabolism and Multiple Stress Responses

The Gram-positive pathogen Clostridioides difficile is the main bacterial agent of nosocomial antibiotic associated diarrhea. Bacterial peptidyl-prolyl-cis/trans-isomerases (PPIases) are well established modulators of virulence that influence the outcome of human pathologies during infections. Here,...

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Bibliographic Details
Main Authors: Can Murat Ünal, Mustafa Safa Karagöz, Mareike Berges, Christina Priebe, José Manuel Borrero de Acuña, Josef Wissing, Lothar Jänsch, Dieter Jahn, Michael Steinert
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Pharmacology
Subjects:
Clostridium difficile
peptidyl-prolyl-cis/trans-isomerase (PPIase)
cytotoxicity
interactomics
transcription
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00340/full

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https://www.frontiersin.org/article/10.3389/fphar.2019.00340/full

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