Identification and characterization of in vivo, in vitro and reactive metabolites of vandetanib using LC–ESI–MS/MS

Identification and characterization of in vivo, in vitro and reactive metabolites of vandetanib using LC–ESI–MS/MS

Abstract Vandetanib (Caprelsa tablets, VNT) is an orally inhibitor of vascular endothelial growth factor receptor 2. The current research reports the characterization and identification of in vitro, in vivo and reactive intermediates of VNT. In vitro metabolites of VNT were performed by incubation w...

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Bibliographic Details
Main Authors: Mohamed W. Attwa, Adnan A. Kadi, Hany W. Darwish, Sawsan M. Amer, Nasser S. Al-shakliah
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Chemistry Central Journal
Subjects:
N-methyl piperidine
Vandetanib
In vivo metabolites
In vitro metabolites
Cyano conjugates
Online Access:http://link.springer.com/article/10.1186/s13065-018-0467-5

Internet

http://link.springer.com/article/10.1186/s13065-018-0467-5

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