Coexpression of GSK-3β Corrects Phenotypic Aberrations of Dorsal Root Ganglion Cells, Cultured from Adult Transgenic Mice Overexpressing Human Protein tau

Coexpression of GSK-3β Corrects Phenotypic Aberrations of Dorsal Root Ganglion Cells, Cultured from Adult Transgenic Mice Overexpressing Human Protein tau

Coexpression of constitutively active GSK-3β[S9A] rescued the axonal pathology induced by overexpression of human tau in transgenic mice (Spittaels et al., (2000) J. Biol. Chem. 275, 41340–41349). We isolated dorsal root ganglion (DRG) neuronal cultures from adult tau4R- and tau4R × GSK-3β-transgeni...

Full description

Bibliographic Details
Main Authors: R. Nuydens, G. Van Den Kieboom, C. Nolten, C. Verhulst, P. Van Osta, K. Spittaels, C. Van den Haute, E. De Feyter, H. Geerts, F. Van Leuven
Format: Article
Language:English
Published: Elsevier 2002-02-01
Series:Neurobiology of Disease
Subjects:
tau
GSK-3β
microtubules
dorsal root ganglion neuron
transgenics
axonal transport
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996101904541

Internet

http://www.sciencedirect.com/science/article/pii/S0969996101904541

Similar Items