Lipopolysaccharide Increases Cortical Kynurenic Acid and Deficits in Reference Memory in Mice
Kynurenic acid (KYNA), a glial-derived metabolite of tryptophan metabolism, is an antagonist of the alpha 7 nicotinic acetylcholine receptor and the glycine-binding site of N -methyl- d -aspartate (NMDA) receptors. Kynurenic acid levels are increased in both the brain and cerebrospinal fluid of seve...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2019-12-01
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| Series: | International Journal of Tryptophan Research |
| Online Access: | https://doi.org/10.1177/1178646919891169 |