Neonatal administration of fluoxetine did not alter the anxiety indicators, but decreased the locomotor activity in adult rats in the elevated plus-maze Administração neonatal de fluoxetina não alterou os indicadores de ansiedade, mas diminuiu a atividade locomotora em ratos adultos no labirinto elevado em cruz

Neonatal administration of fluoxetine did not alter the anxiety indicators, but decreased the locomotor activity in adult rats in the elevated plus-maze Administração neonatal de fluoxetina não alterou os indicadores de ansiedade, mas diminuiu a atividade locomotora em ratos adultos no labirinto elevado em cruz

The objective of this study was evaluate the anxiety and locomotor activity (LA) in 52 Wistar adult male rats, being 26 treated with fluoxetine (10 mg/Kg - sc) in the neonatal period. These same rats received foot shock (FS) (1.6-mA - 2-s) in the 90th day. The anxiety and LA were appraised by plus-m...

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Bibliographic Details
Main Authors: Valdenilson Ribeiro Ribas, Helena Karine Rufino Aniceto, Hugo André de Lima Martins, Ketlin Helenise dos Santos Ribas, Renata de Melo Guerra-Ribas, Simone do Nascimento Fraga, Valéria Ribeiro-Ribas, Célia Maria Mendes Vasconcelos, Marcelo Tavares Viana, Raul Manhaes-de-Castro
Format: Article
Language:English
Published: Academia Brasileira de Neurologia (ABNEURO) 2008-12-01
Series:Arquivos de Neuro-Psiquiatria
Subjects:
ansiedade
labirinto elevado em cruz
serotonina
fluoxetina
neonatal
anxiety
plus-maze
serotonin
fluoxetine
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000600013

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000600013

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