11C-UCB-J synaptic PET and multimodal imaging in dementia with Lewy bodies

11C-UCB-J synaptic PET and multimodal imaging in dementia with Lewy bodies

Abstract Objective Dementia with Lewy bodies (DLB) is a common cause of dementia, but atrophy is mild compared to Alzheimer’s disease. We propose that DLB is associated instead with severe synaptic loss, and we test this hypothesis in vivo using positron emission tomography (PET) imaging of 11C-UCB-...

Full description

Bibliographic Details
Main Authors: Nicolas Nicastro, Negin Holland, George Savulich, Stephen F. Carter, Elijah Mak, Young T. Hong, Selena Milicevic Sephton, Tim D. Fryer, Franklin I. Aigbirhio, James B. Rowe, John T. O’Brien
Format: Article
Language:English
Published: SpringerOpen 2020-12-01
Series:European Journal of Hybrid Imaging
Subjects:
Synaptic imaging
Dementia
Lewy bodies
Amyloid
Tau
Brain atrophy
Online Access:https://doi.org/10.1186/s41824-020-00093-9

Internet

https://doi.org/10.1186/s41824-020-00093-9

Similar Items