Study on the potential nephrotoxicity and mutagenicity of aristolochic acid IVa and its mechanism

Study on the potential nephrotoxicity and mutagenicity of aristolochic acid IVa and its mechanism

Previous reports demonstrated that aristolochic acids (AAs) exposure-induced nephrotoxicity, mutations, and tumorigenesis are mainly due to aristolochic acid I (AAI). Notably, the chemical structure of aristolochic acid IVa (AAIVa), which exists at higher levels in many Aristolochiaceae herbs, is ex...

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Bibliographic Details
Main Authors: Zhong Xian, Jingzhuo Tian, Yushi Zhang, Jing Meng, Yong Zhao, Chunying Li, Yan Yi, Jiayin Han, Suyan Liu, Lianmei Wang, Chen Pan, Dunfang Wang, Fang Wang, Aihua Liang
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Aristolochic acid IVa
Nephrotoxicity
Low mutagenicity
Low carcinogenicity
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221008647

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http://www.sciencedirect.com/science/article/pii/S0753332221008647

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