Selective attenuation of norepinephrine release and stress-induced heart rate increase by partial adenosine A1 agonism.

The release of the neurotransmitter norepinephrine (NE) is modulated by presynaptic adenosine receptors. In the present study we investigated the effect of a partial activation of this feedback mechanism. We hypothesized that partial agonism would have differential effects on NE release in isolated...

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Bibliographic Details
Main Authors: Lorenz Bott-Flügel, Alexandra Bernshausen, Heike Schneider, Peter Luppa, Katja Zimmermann, Barbara Albrecht-Küpper, Raimund Kast, Karl-Ludwig Laugwitz, Heimo Ehmke, Andreas Knorr, Melchior Seyfarth
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3065468?pdf=render