Microsomal Prostaglandin E Synthase-1 Expression in Inflammatory Conditions Is Downregulated by Dexamethasone: Seminal Role of the Regulatory Phosphatase MKP-1

Microsomal Prostaglandin E Synthase-1 Expression in Inflammatory Conditions Is Downregulated by Dexamethasone: Seminal Role of the Regulatory Phosphatase MKP-1

Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible enzyme situated downstream of cyclo-oxygenase-2, promoting the excessive PGE2 production in inflammation. Dexamethasone is known to suppress mPGES-1 but the mechanisms regulating mPGES-1 expression remain poorly known. MKP-1 is a phosph...

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Bibliographic Details
Main Authors: Lauri Tuure, Mari Hämäläinen, Brendan J. Whittle, Eeva Moilanen
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Pharmacology
Subjects:
mPGES-1
prostaglandins
MAP kinases
MKP-1
JNK
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00646/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00646/full

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