Induction of IgE synthesis by genetically modified CD8+ T cells of a patient with adenosine deaminase deficiency

Induction of IgE synthesis by genetically modified CD8+ T cells of a patient with adenosine deaminase deficiency

We have previously reported that an adenosine deaminase (ADA)-deficient patient treated with T cell-directed gene therapy had an increase in serum IgE levels, despite a marked inversion of the CD4/CD8 ratio. In the present report, we have analyzed the phenotypic and functional profiles of the patien...

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Bibliographic Details
Main Authors: Yukiyoshi Yanagihara, Keiichi Kajiwara, Yuji Basaki, Koichi Ikizawa, Miyuki Mori, Kazuo Akiyama, Nobuaki Kawamura, Yukio Sakiyama
Format: Article
Language:English
Published: Elsevier 2000-01-01
Series:Allergology International
Subjects:
CD40 ligand
CD8+ T cells
gene therapy
IgE production
interleukin-4
Online Access:http://www.sciencedirect.com/science/article/pii/S1323893015314064

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http://www.sciencedirect.com/science/article/pii/S1323893015314064

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