Alternative splicing of ceramide synthase 2 alters levels of specific ceramides and modulates cancer cell proliferation and migration in Luminal B breast cancer subtype

Alternative splicing of ceramide synthase 2 alters levels of specific ceramides and modulates cancer cell proliferation and migration in Luminal B breast cancer subtype

Abstract Global dysregulation of RNA splicing and imbalanced sphingolipid metabolism has emerged as promoters of cancer cell transformation. Here, we present specific signature of alternative splicing (AS) events of sphingolipid genes for each breast cancer subtype from the TCGA-BRCA dataset. We sho...

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Bibliographic Details
Main Authors: Trishna Pani, Kajal Rajput, Animesh Kar, Harsh Sharma, Rituparna Basak, Nihal Medatwal, Sandhini Saha, Gagan Dev, Sharwan Kumar, Siddhi Gupta, Arnab Mukhopadhyay, Dipankar Malakar, Tushar Kanti Maiti, Aneeshkumar G. Arimbasseri, S. V. S. Deo, Ravi Datta Sharma, Avinash Bajaj, Ujjaini Dasgupta
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03436-x

Internet

https://doi.org/10.1038/s41419-021-03436-x

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