Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents

Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents

Radiation damage causes DNA foci to form and senescence, causing ulcers. Here, the authors show that a naturally occurring adenosine analogue, cordycepin, prevents cell senescence via an increase in AMPK/NRF2, so blocking ulcers caused by radiation on skin/intestine/tongue damage in rodents.

Bibliographic Details
Main Authors: Ziwen Wang, Zelin Chen, Zhongyong Jiang, Peng Luo, Lang Liu, Yu Huang, Huilan Wang, Yu Wang, Lei Long, Xu Tan, Dengqun Liu, Taotao Jin, Yawei Wang, Yang Wang, Fengying Liao, Chi Zhang, Long Chen, Yibo Gan, Yunsheng Liu, Fan Yang, Chunji Huang, Hongming Miao, Jieping Chen, Tianmin Cheng, Xiaobing Fu, Chunmeng Shi
Format: Article
Language:English
Published: Nature Publishing Group 2019-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10386-8

Internet

https://doi.org/10.1038/s41467-019-10386-8

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