A Novel Mechanism of Cannabidiol in Suppressing Hepatocellular Carcinoma by Inducing GSDME Dependent Pyroptosis

A Novel Mechanism of Cannabidiol in Suppressing Hepatocellular Carcinoma by Inducing GSDME Dependent Pyroptosis

Cannabidiol (CBD), a phytochemical derived from Cannabis sativa L., has been demonstrated to exhibit promising anti-tumor properties in multiple cancer types. However, the effects of CBD on hepatocellular carcinoma (HCC) cells remain unknown. We have shown that CBD effectively suppresses HCC cell gr...

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Bibliographic Details
Main Authors: Fugen Shangguan, Hongfei Zhou, Nengfang Ma, Shanshan Wu, Huimin Huang, Guihua Jin, Shijia Wu, Weilong Hong, Weiwei Zhuang, Hongping Xia, Linhua Lan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
cannabidiol
hepatocellular carcinoma
pyroptosis
integrative stress response
aerobic glycolysis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.697832/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.697832/full

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