Synthesis, biological activity and molecular docking of new tricyclic series as α-glucosidase inhibitors

Synthesis, biological activity and molecular docking of new tricyclic series as α-glucosidase inhibitors

Abstract Diabetes is an emerging metabolic disorder. α-Glucosidase inhibitors, such as acarbose, delay the hydrolysis of carbohydrates by interfering with the digestive enzymes. This action decreases the glucose absorption and the postprandial glucose level. We have synthesized 25 tricyclic 2-phenox...

Full description

Bibliographic Details
Main Authors: Hatem A. Abuelizz, Nor Azman N. I. Iwana, Rohaya Ahmad, El-Hassane Anouar, Mohamed Marzouk, Rashad Al-Salahi
Format: Article
Language:English
Published: BMC 2019-04-01
Series:BMC Chemistry
Subjects:
Pyrido-triazolopyrimidine
α-Glucosidase
Antidiabetic
Acarbose
Molecular docking
Online Access:http://link.springer.com/article/10.1186/s13065-019-0560-4

Internet

http://link.springer.com/article/10.1186/s13065-019-0560-4

Similar Items