Borneol and Α-asarone as adjuvant agents for improving blood–brain barrier permeability of puerarin and tetramethylpyrazine by activating adenosine receptors

Borneol and Α-asarone as adjuvant agents for improving blood–brain barrier permeability of puerarin and tetramethylpyrazine by activating adenosine receptors

Puerarin (PUE) and tetramethylpyrazine (TMP) are central nervous system (CNS) drugs used in cerebrovascular diseases. Poor brain–blood barrier (BBB) permeability limited their clinical application. Borneol and α-asarone have been proposed as an oral brain-targeting enhancer. In this study, we aimed...

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Bibliographic Details
Main Authors: Jun-Yong Wu, Yong-Jiang Li, Le Yang, Yi-Yun Hu, Xiong-Bin Hu, Tian-Tian Tang, Jie-Min Wang, Xin-Yi Liu, Da-Xiong Xiang
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Drug Delivery
Subjects:
borneol
α-asarone
puerarin
tetramethylpyrazine
blood–brain barrier
adenosine receptor
Online Access:http://dx.doi.org/10.1080/10717544.2018.1516005

Internet

http://dx.doi.org/10.1080/10717544.2018.1516005

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