Increased Endogenous GDNF in Mice Protects Against Age-Related Decline in Neuronal Cholinergic Markers

Increased Endogenous GDNF in Mice Protects Against Age-Related Decline in Neuronal Cholinergic Markers

Gradual decline in cholinergic transmission and cognitive function occurs during normal aging, whereas pathological loss of cholinergic function is a hallmark of different types of dementia, including Alzheimer’s disease (AD), Lewy body dementia (LBD), and Parkinson’s disease dementia (PDD). Glial c...

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Bibliographic Details
Main Authors: Sumonto Mitra, Giorgio Turconi, Taher Darreh-Shori, Kärt Mätlik, Matilde Aquilino, Maria Eriksdotter, Jaan-Olle Andressoo
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
glial cell line-derived neurotrophic factor (GDNF)
nerve growth factor (NGF)
aging
cholinergic markers
cholinergic index
choline acetyltransferase (ChAT)
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.714186/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2021.714186/full

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