Exosome-Depleted Excretory-Secretory Products of the Fourth-Stage Larval Angiostrongylus cantonensis Promotes Alternative Activation of Macrophages Through Metabolic Reprogramming by the PI3K-Akt Pathway

Exosome-Depleted Excretory-Secretory Products of the Fourth-Stage Larval Angiostrongylus cantonensis Promotes Alternative Activation of Macrophages Through Metabolic Reprogramming by the PI3K-Akt Pathway

Angiostrongylus cantonensis (AC), which parasitizes in the brain of the non-permissive host, such as mouse and human, is an etiologic agent of eosinophilic meningitis. Excretory-secretory (ES) products play an important role in the interaction between parasites and hosts’ immune responses. Inflammat...

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Bibliographic Details
Main Authors: Shuo Wan, Xiaoqiang Sun, Wenyan Tang, Lifu Wang, Zhongdao Wu, Xi Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
Angiostrongylus cantonensis
exosome-depleted excretory-secretory products
N-linked glycoproteins
macrophage polarization
mechanism
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.685984/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.685984/full

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