Laboratory Mice Are Frequently Colonized with Staphylococcus aureus and Mount a Systemic Immune Response—Note of Caution for In vivo Infection Experiments

Laboratory Mice Are Frequently Colonized with Staphylococcus aureus and Mount a Systemic Immune Response—Note of Caution for In vivo Infection Experiments

Whether mice are an appropriate model for S. aureus infection and vaccination studies is a matter of debate, because they are not considered as natural hosts of S. aureus. We previously identified a mouse-adapted S. aureus strain, which caused infections in laboratory mice. This raised the question...

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Bibliographic Details
Main Authors: Silva Holtfreter, Daniel Schulz, Dorothee Grumann, Patricia Trübe, Kathleen Pritchett-Corning, Sarah Johnson, Kevin Reppschläger, Janine Gumz, Nandakumar Sundaramoorthy, Stephan Michalik, Sabine Berg, Jens van den Brandt, Richard Fister, Stefan Monecke, Benedict Uy, Frank Schmidt, Barbara M. Bröker, Siouxsie Wiles
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Staphylococcus aureus
colonization
antibody
laboratory mice
host adaptation
genotype
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2017.00152/full

Internet

http://journal.frontiersin.org/article/10.3389/fcimb.2017.00152/full

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