Role for Retinoic Acid-Related Orphan Receptor Alpha (RORα) Expressing Macrophages in Diet-Induced Obesity

Role for Retinoic Acid-Related Orphan Receptor Alpha (RORα) Expressing Macrophages in Diet-Induced Obesity

The transcription factor RORα plays an important role in regulating circadian rhythm, inflammation, metabolism, and cellular development. Herein we show a role for RORα-expressing macrophages in the adipose tissue in altering the metabolic state of mice on a high-fat diet. The expression of Rora and...

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Bibliographic Details
Main Authors: Emily Hams, Joseph Roberts, Rachel Bermingham, Andrew E. Hogan, Donal O'Shea, Luke O'Neill, Padraic G. Fallon
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
RORα
macrophage
inflammation
metabolism
obesity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01966/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01966/full

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