ApoE2-associated hypertriglyceridemia is ameliorated by increased levels of apoA-V but unaffected by apoC-III deficiency*

ApoE2-associated hypertriglyceridemia is ameliorated by increased levels of apoA-V but unaffected by apoC-III deficiency*

Apolipoprotein E2 (apoE2)-associated hyperlipidemia is characterized by a disturbed clearance of apoE2-enriched VLDL remnants. Because excess apoE2 inhibits LPL-mediated triglyceride (TG) hydrolysis in vitro, we investigated whether direct or indirect stimulation of LPL activity in vivo reduces the...

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Bibliographic Details
Main Authors: Gery Gerritsen, Caroline C. van der Hoogt, Frank G. Schaap, Peter J. Voshol, Kyriakos E. Kypreos, Nobuyo Maeda, Albert K. Groen, Louis M. Havekes, Patrick C.N. Rensen, Ko Willems van Dijk
Format: Article
Language:English
Published: Elsevier 2008-05-01
Series:Journal of Lipid Research
Subjects:
apolipoprotein E2
apolipoprotein A-V
apolipoprotein C-III
APOE2-knockin mice
lipoprotein lipase-mediated very low density lipoprotein-triglyceride hydrolysis
adenovirus-mediated gene transfer
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520425921

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http://www.sciencedirect.com/science/article/pii/S0022227520425921

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