Investigation of Enantioselective Membrane Permeability of α-Lipoic Acid in Caco-2 and MDCKII Cell

Investigation of Enantioselective Membrane Permeability of α-Lipoic Acid in Caco-2 and MDCKII Cell

α-Lipoic acid (LA) contains a chiral carbon and exists as two enantiomers (R-α-lipoic acid (RLA) and S-α-lipoic acid (SLA)). We previously demonstrated that oral bioavailability of RLA is better than that of SLA. This difference arose from the fraction absorbed multiplied by gastrointestinal availab...

Full description

Bibliographic Details
Main Authors: Ryota Uchida, Hinako Okamoto, Naoko Ikuta, Keiji Terao, Takashi Hirota
Format: Article
Language:English
Published: MDPI AG 2016-01-01
Series:International Journal of Molecular Sciences
Subjects:
α-lipoic acid
pharmacokinetics
enantioselective
membrane permeability
gastrointestinal availability
hepatic availability
Caco-2
MDCKII
Online Access:http://www.mdpi.com/1422-0067/17/2/155

Internet

http://www.mdpi.com/1422-0067/17/2/155

Similar Items