Cyp2j5-Gene Deletion Affects on Acetylcholine and Adenosine-Induced Relaxation in Mice: Role of Angiotensin-II and CYP-Epoxygenase Inhibitor

Cyp2j5-Gene Deletion Affects on Acetylcholine and Adenosine-Induced Relaxation in Mice: Role of Angiotensin-II and CYP-Epoxygenase Inhibitor

Previously, we showed vascular endothelial overexpression of human-CYP2J2 enhances coronary reactive hyperemia in Tie2-CYP2J2 Tr mice, and eNOS−/− mice had overexpression of CYP2J-epoxygenase with adenosine A2A receptor-induced enhance relaxation, but we did not see the response in CYP2J-epoxygenase...

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Bibliographic Details
Main Authors: Stephanie Agba, Ahmad Hanif, Matthew L. Edin, Darryl C. Zeldin, Mohammed A. Nayeem
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Pharmacology
Subjects:
CYP-epoxygenases
acetylcholine
adenosine
adenosine A2A receptor
angiotensin-II
relaxation
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00027/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00027/full

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