Glutamine-expanded ataxin-7 alters TFTC/STAGA recruitment and chromatin structure leading to photoreceptor dysfunction.

Glutamine-expanded ataxin-7 alters TFTC/STAGA recruitment and chromatin structure leading to photoreceptor dysfunction.

Spinocerebellar ataxia type 7 (SCA7) is one of several inherited neurodegenerative disorders caused by a polyglutamine (polyQ) expansion, but it is the only one in which the retina is affected. Increasing evidence suggests that transcriptional alterations contribute to polyQ pathogenesis, although t...

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Bibliographic Details
Main Authors: Dominique Helmlinger, Sara Hardy, Gretta Abou-Sleymane, Adrien Eberlin, Aaron B Bowman, Anne Gansmüller, Serge Picaud, Huda Y Zoghbi, Yvon Trottier, Làszlò Tora, Didier Devys
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-03-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.0040067

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https://doi.org/10.1371/journal.pbio.0040067

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