Glutamine-expanded ataxin-7 alters TFTC/STAGA recruitment and chromatin structure leading to photoreceptor dysfunction.
Spinocerebellar ataxia type 7 (SCA7) is one of several inherited neurodegenerative disorders caused by a polyglutamine (polyQ) expansion, but it is the only one in which the retina is affected. Increasing evidence suggests that transcriptional alterations contribute to polyQ pathogenesis, although t...
Main Authors: | Dominique Helmlinger, Sara Hardy, Gretta Abou-Sleymane, Adrien Eberlin, Aaron B Bowman, Anne Gansmüller, Serge Picaud, Huda Y Zoghbi, Yvon Trottier, Làszlò Tora, Didier Devys |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2006-03-01
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Series: | PLoS Biology |
Online Access: | https://doi.org/10.1371/journal.pbio.0040067 |
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