Collagen Specific T-Cell Repertoire and HLA-DR Alleles: Biomarkers of Active Refractory Rheumatoid Arthritis

Collagen Specific T-Cell Repertoire and HLA-DR Alleles: Biomarkers of Active Refractory Rheumatoid Arthritis

Rheumatoid arthritis (RA) is characterized by chronic joint inflammation and associates with HLA-DRB1*04. The Collagen IIp261-273-specific T cell repertoire in the peripheral blood of DR4+ patients at the onset of the disease shows a restricted TCR-beta chain usage among which the most frequent is T...

Full description

Bibliographic Details
Main Authors: Gabriele Di Sante, Barbara Tolusso, Anna Laura Fedele, Elisa Gremese, Stefano Alivernini, Chiara Nicolò, Francesco Ria, Gianfranco Ferraccioli
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:EBioMedicine
Subjects:
HLA-DRB1
Disease activity
ACPA
TRBV 25
Clonotypes
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396415302036

Internet

http://www.sciencedirect.com/science/article/pii/S2352396415302036

Similar Items