Stochastic Variation in Expression of the Tricarboxylic Acid Cycle Produces Persister Cells

Stochastic Variation in Expression of the Tricarboxylic Acid Cycle Produces Persister Cells

Persister cells are rare phenotypic variants that are able to survive antibiotic treatment. Unlike resistant bacteria, which have specific mechanisms to prevent antibiotics from binding to their targets, persisters evade antibiotic killing by entering a tolerant nongrowing state. Persisters have bee...

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Bibliographic Details
Main Authors: Eliza A. Zalis, Austin S. Nuxoll, Sylvie Manuse, Geremy Clair, Lauren C. Radlinski, Brian P. Conlon, Joshua Adkins, Kim Lewis
Format: Article
Language:English
Published: American Society for Microbiology 2019-09-01
Series:mBio
Subjects:
staphylococcus aureus
bioenergetics
heterologous gene expression
metabolism
persistence
tolerance
Online Access:https://doi.org/10.1128/mBio.01930-19

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