Ovatodiolide Suppresses Oral Cancer Malignancy by Down-Regulating Exosomal Mir-21/STAT3/β-Catenin Cargo and Preventing Oncogenic Transformation of Normal Gingival Fibroblasts

Ovatodiolide Suppresses Oral Cancer Malignancy by Down-Regulating Exosomal Mir-21/STAT3/β-Catenin Cargo and Preventing Oncogenic Transformation of Normal Gingival Fibroblasts

Oral squamous cell carcinoma (OSCC) is among the most commonly diagnosed malignancies in the world. Patients with OSCC often develop treatment resistance, resulting in a poor prognosis. Mounting evidence indicates that interactions between cancerous cells and other components of the tumor microenvir...

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Bibliographic Details
Main Authors: Jia-Hong Chen, Alexander T. H. Wu, Oluwaseun Adebayo Bamodu, Vijesh Kumar Yadav, Tsu-Yi Chao, Yew-Min Tzeng, Debabrata Mukhopadhyay, Michael Hsiao, Jih-Chin Lee
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:Cancers
Subjects:
oral squamous cell carcinoma
ovatodiolide
extracellular vesicles
tumor microenvironment
cancer-associated fibroblasts
mir-21-5p/stat3/β-catenin signaling
Online Access:https://www.mdpi.com/2072-6694/12/1/56

Internet

https://www.mdpi.com/2072-6694/12/1/56

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